Bi-directional cell-pericellular matrix interactions direct stem cell fate
نویسندگان
چکیده
منابع مشابه
Matrix Control of Stem Cell Fate
A key challenge in stem cell research is to learn how to direct the differentiation of stem cells toward specific fates. In this issue of Cell, Engler et al. (2006) identify a new factor regulating stem cell fate: the elasticity of the matrix microenvironment. By changing the stiffness of the substrate, human mesenchymal stem cells could be directed along neuronal, muscle, or bone lineages.
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Masellis-Smith, A., Belch, A. R., Mant, M. J., ‘I’urley, E. A. and Pilarski, I,. M. (1996) Blood 87, I891 I899 ‘L’urley, E. A. and Torrance, J. (1984) Exp. Cell Kes. 161, 17-28 Weiss, J. M., Kenkl, A. C., Ahrens, ‘I-., Moll, J., Mai, B. €I., Denfeld, R. W., Schopf, E., Ponta, I I . , IIerrlich, P. and Simon, J. C. (1998) J. Invest. Dermatol. 111, 227-232 ‘I’eder, P. and Heldin, P. (1997) Am. J....
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-06183-4